Policy Issue Date : October 2008
Multi-resistant gram negative rods: A variety of gram negative bacteria which have extensive resistance to common antibiotics. Examples include ESBL producing E. Coli and Klebsiella species, Pseudomonas aeroginosa, Actinetobacter baumanii and Stenotrophomonas maltophilia.
ESBL: Extended Spectrum Beta-Lactamase.
ESBLs are enzymes produced by some species of gram negative bacteria such as E. Coli and Klebsiella. These bacteria are predominantly bowel organisms. ESBLs have the ability to destroy a wide range of Beta-Lactam antibiotics including common agents such as Co-amoxiclav, Amoxicillin and Cephalosporins. Organisms with an ESBL often carry resistance to other classes of antibiotics such as Ciprofloxacin and Trimethoprim. These first-line antibiotics are no longer effective for infections caused by ESBL-producing bacteria.
Notes on Infections with ESBL